Sulforaphane SFN an isothiocyanate found in Red cabbage possess anticancer, antioxidant and antimicrobial activities. The objective of the study was to examine antioxidant activity of purified SFN in terms of 1,1 diphenyl 2 picryl hydrazyl (DPPH) and the levels of Glutathione S Transferase (GST) and reduced glutathione (GSH) in Vero and HEp- 2 cells. The results indicated that extract possess higher radical scavenging activity in HEp-2 and Vero cells when compared to purified SFN. Purified and Std SFN found to have closer radical scavenging activity in Vero and HEp-2 cells. GST, GSH levels in SFN treated Vero and HEp-2 cells were decreased when compared to control cells. The antimicrobial activity of purified SFN was done by diffusion method. Purified SFN was found to possess good antimicrobial activity against bacterial and fungal species. The study showed that purified SFN and Extract may exert its antioxidant stress by scavenging free radicals and controlling xenobiotic metabolism in Vero and HEp-2 cells

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