Aim of work: Assess Coriandrum sativum essential oil for its chemical composition, hypoglycemic effect, antioxidant activity on glutathione perioxidase and antidiabetic effects on pancreas and kidney in streptozotocin induced diabetic rats. Materials and Methods: Thirty male albino rats were divided into three groups where diabetes was induced in two groups of them. Coriandrum sativum essential oil was analysed using gas chromatography, and administered to a group of them (40 mg/kg b.w. orally) for 21 days according to its LD50. Serum glucose and glutathione were measured in addition to histological examination of kidney and pancreas. Results: The major components of coriander oil are linalool (40.9%), geranyl acetate (12.8%) and γ-terpinene (10.6%) . In the diabetic group coriander essential oil significantly reduced serum glucose from 162.5±3.19 (mg/dl) to 72.96±1.73 (mg/dl);(p<0.05) and increased glutathione peroxidase level from 59.72±2.78 (u/g Hb) to 124.83±2.31(u/g Hb);(p<0.05) . The kidney and pancreas of the diabetic rats subjected to coriander showed some protective effects against diabetic pathological changes. Conclusion: Our findings confirm the hypoglycemic and antioxidant activity of Coriandrum sativum L. oil, besides improving kidney and pancreas pathological changes as a result of induction of diabetes. These could be contributed to the synergistic action of its bioactive compounds.

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