ABSTRACT:\n The purpose of this study is to investigate the protective effect of taurine against photochemical damage in rabbit retina. Twenty seven rabbits were divided into three groups control group (A), exposed to light without (B) and with taurine (C). Groups B and C were divided into four subgroups according to the time of exposure to white light (3, 6, 12 and 24 hr). Group C treated with taurine (4 g taurine /100 g diet) for 2 weeks before exposure to white light (2500± 100 lux). Retinal function was assessed by electroretinogram (ERG). The comet assay also was used to examine qualitative and quantitative aspects of DNA. Statistically significant reduction in a- and b - waves was apparent (p < 0.05) in group (B) that exposed to light to reach maximum reduction after 24 hr of exposure, the percentage difference was 81 % and 83 % for a-and b- waves respectively. The reduction of a-and b- wave amplitude after light exposure was attenuate by taurine intake. Also the extent of DNA damage increased proportionately with increasing time of exposure to white light that appear in elevated mean percentage tail DNA and tail moment reached to 6.16±0.4% and 14.2% respectively at 24 hr of exposure to white light. Taurine effect was appeared clearly by decrease this percentage to be 3.3±0.2% and 5.2% for the same group. Our results underscore the importance of taurine that played neuroprotective role in retina after exposed to white light.

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