antimicrobial resistance multidrug resistance pathogens carbapenems Enterobacteriaceae Staphylococcus aureus

Antimicrobial resistance (AMR) represents a significant global health challenge, exacerbating the burden of infectious diseases. This study aims to explore AMR patterns in various pathogenic microorganisms across different geographic regions. We collected and analyzed clinical isolates from hospitals affiliated with Chiang Mai University in Thailand, Baku State University in Azerbaijan, and the University of Nairobi in Kenya. Utilizing panel-based susceptibility testing, we identified resistance profiles against commonly prescribed antibiotics. Our findings indicate a worrying prevalence of multi-drug resistant strains, particularly in Enterobacteriaceae and Staphylococcus aureus, which demonstrated significant resistance to last-line treatments such as carbapenems and vancomycin, respectively. The data underscores the critical necessity for robust AMR surveillance systems and the development of novel therapeutic strategies. The study concludes that coordinated international efforts are required to address the escalation of AMR, emphasizing the importance of policy reforms and investment in research and development of new antimicrobials. Future research should focus on the genetic and environmental factors driving resistance to better tailor intervention measures.

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