The present study was conducted to study the effect of the methanolic extract of Bacopa monnieri leaves on the extent of cell death under conditions of oxidative stress. The cells used were Saccharomyces cerevisiae cells and the oxidant used to induce oxidative stress was H2O2. The cells were subjected to oxidative stress and the effect of the extract in counteracting this stress was assessed by analyzing characteristic apoptotic events. The results obtained clearly indicated that the exposure to H2O2 resulted in a steep rise in the number of \nS. cerevisiae cells undergoing apoptosis. Bacopa monnieri leaf extract, by itself, did not cause an increase in the extent of apoptosis. When co-administered along with H2O2, the plant extract resulted in a markedly decreased number of apoptotic cells. Thus, it is evident that the methanolic extract of Bacopa monnieri leaves protects the yeast cells from oxidative stress-induced death.