📚 Volume 30, Issue 5
📋 ID: uFukBhI
Authors
muntecep askar ,Ozge Karakilic,Ayfer Meral,Mehmet Parlak, Nuruban delal azarkan,Selvi Askar
Department of Cardiology, Van Yuzuncu Yil University Medical Faculty, Van, Turkey Turkey
Abstract
Background
Alpha 1 Antitrypsin (AAT) plays a crucial role in protecting the lungs from the damage caused by excessive inflammation.It is known that intense inflammation manifests in COVID-19 (SARS-CoV-2) pneumonia. The aim of this study was to measure AAT levels in COVID-19 pneumonia patients and to predict AAT treatment in these patients.
Methods
This cross-sectional, clinical study included 154(61 females, 93 males) COVID-19 pneumonia patients. The age, sex, biochemical parameters and survival information of the patients were recorded. The independent variables affecting the AAT level were examined by linear regression analysis, and the regression model was found to be statistically significant(F=3.051; p=0.001).
Results
There was no correlation between AAT mean values and survival (p=0.133). While the AAT level decreased by 0.003 units as the CRP value increased by 1 unit (p=0.003), AAT level decreased by 0.027 units as the lymphocyte value increased by 1 unit (p=0.001). As the neutrophil value increased by 1 unit, the AAT level decreased by 0.019 units (p=0.014). There was no statistically significant effect of other independent variables (p>0.050).
Conclusion
The negative correlation between rising inflammatory indicators and AAT levels in pneumonia patients shows that defense mechanisms got weakened. In patients with a viral infection, AAT may have an antiviral effect due to its regulatory and anti-replication effects on both inflammation and the immune system. Although there is no significant relationship between AAT level and survival, the negative correlation between AAT and inflammation indicators may suggest that AAT treatment may be effective in these patients.
Alpha 1 Antitrypsin (AAT) plays a crucial role in protecting the lungs from the damage caused by excessive inflammation.It is known that intense inflammation manifests in COVID-19 (SARS-CoV-2) pneumonia. The aim of this study was to measure AAT levels in COVID-19 pneumonia patients and to predict AAT treatment in these patients.
Methods
This cross-sectional, clinical study included 154(61 females, 93 males) COVID-19 pneumonia patients. The age, sex, biochemical parameters and survival information of the patients were recorded. The independent variables affecting the AAT level were examined by linear regression analysis, and the regression model was found to be statistically significant(F=3.051; p=0.001).
Results
There was no correlation between AAT mean values and survival (p=0.133). While the AAT level decreased by 0.003 units as the CRP value increased by 1 unit (p=0.003), AAT level decreased by 0.027 units as the lymphocyte value increased by 1 unit (p=0.001). As the neutrophil value increased by 1 unit, the AAT level decreased by 0.019 units (p=0.014). There was no statistically significant effect of other independent variables (p>0.050).
Conclusion
The negative correlation between rising inflammatory indicators and AAT levels in pneumonia patients shows that defense mechanisms got weakened. In patients with a viral infection, AAT may have an antiviral effect due to its regulatory and anti-replication effects on both inflammation and the immune system. Although there is no significant relationship between AAT level and survival, the negative correlation between AAT and inflammation indicators may suggest that AAT treatment may be effective in these patients.
📝 How to Cite
muntecep askar ,Ozge Karakilic,Ayfer Meral,Mehmet Parlak, Nuruban delal azarkan,Selvi Askar (2023). "Can Alpha 1 Antitrypsin (AAT) be Considered in the Treatment of Covid-19 (SARS-CoV-2)?". Wulfenia, 30(5).