One of the most important public health issues is antimicrobial resistance. Carduus getulus Pomel(family Asteraceae), known as hashroof by Egyptians, is wild annual plant. The present study aims to evaluate the antioxidant and antimicrobial activities of C. getulus collected from coastal desert. In the investigated plant, total phenolics, tannins, alkaloids, flavonoids, saponins, glucosides, and steroids were measured. The antioxidant activity was measured based on the reduction of DPPH. The IC50 values of the antioxidant inhibition of C. getuluswas 43.32 mg ml-1 compared to control. In this investigation, the methyl alcohol extract of C. getulus has a high broad spectrum (89 percent) of antibacterial activity against the microorganisms tested. The pathogen Escherichia coli, Pseudomonas aeruginosaand Staphylococcus aureus(17.22, 16.33 and 16.18 mm, respectively) were the most sensitive bacteria. In conclusion, C. getulus extracts can be employed as natural antioxidant and antibacterial agents in pharmacotherapy, according to this study.