Air quality in Tirana (Albania) was assessed by daily measurements of PM2.5, Al, and Pb in June 2021. Al and Pb concentrations in PM2.5 samples were quantified on Teflon-coated glass fiber filter samplers along five monitoring sites in Tirana city. The measurements were carried out in three heavy traffic crossroads and two residential areas during a summer day with elevated air temperatures up to 23 ℃. The results of PM2.5, and Al and Pb in solid particles of PM2.5 were discussed through data treatment through statistical analysis. A moderate variation (25% < CV% < 75%) was found for all parameters under investigation. Site concentration data were compared with the respective recommended values of the European Directives for each parameter. The results showed higher concentration levels compared with the allowed data for rural and residential areas, but lower than the recommended values for urban and industrial areas, throughout all stations. Correlation analysis revealed high and significant correlations (r > 0.85, p < 0.05) between all concentration data (PM2.5-Al; PM2.5-Pb, and Al-Pb) indicating a high effect of particulate matter on airborne Al and Pb content. It may cause an increase in human exposure to harmful pollutants through inhalation and could lead to harmful health problems. Stronger mases and measures are proposed to improve air quality in Tirana city.