The purpose of this research is to evaluate the vegetation and plant diversity in the northern sector of the Eastern Desert in relation to edaphic factors at three wadis (Wadi Hagoul, Wadi El-Rashrash, and Wadi Al-Atfihi). The total number of the recorded plant species surveyed in the present study is 87 species (31 annuals, two biennial and 54 perennials) belonging to 70 genera and related to 27 families. Asteraceae, Fabaceae, Poaceae and Chenopodiaceae are leading taxa and constitute the major bulk of the flora of the study area. The majority of the recorded species are therophytes (37.93%) followed by chamaephytes (32.18%). Chorological analysis of the surveyed flora (Table 2) revealed that, 67 species represented by 77.02% of the total number of recorded species are Saharo-Sindian taxa. In the present study, the application of TWINSPAN classification on the importance values (out of 200) of 87 plant species representing, led to the recognition of four vegetation groups. Among the most common plants you\'ll come across are Ochradenus baccatus, Retama raetam, Zygophyllum coccineum and Zilla spinosa. In the northern part of the Eastern Desert, the distribution of flora is mostly determined by soil physical qualities, soil salinity, and human activities.