Sepsis remains one of the most common diseases occurring during the neonatal period, and is still a significant cause of morbidity and mortality (1), despite considerable advances in hygiene, the introduction of new antimicrobial agents and advanced measures for early diagnosis. This accounts for 13-15% of deaths during the neonatal period, with this figure being higher in developing countries with rates of 30-50%. Sepsis-related mortality is prevented with rational antimicrobial therapy, nutrition, and aggressive supportive care. The general objective of the article produced here was to carry out a literature review on the diagnosis by molecular methodology of bacterial resistance in strata of Staphylococcus epidermides, in the blood of newborns with suspected bacterial resistance or not.