Rhabdomyolysis due to hypothyroidism is uncommon, and there have been few case reports of repeated rhabdomyolysis in patients with hypothyroidism. We report a rare case of repeated rhabdomyolysis in a patient with hypothyroidism. The patient was a 65-year-old Japanese male who presented to an outside hospital with bilateral lower extremity weakness; he was diagnosed with hypothyroidism and successfully treated with levothyroxine. His symptoms and laboratory parameters improved with treatment such that he was safely discharged. However, the patient was non-compliant with his levothyroxine beginning at 10 weeks after his discharge and re-presented with bilateral lower extremity weakness and myalgias 18 weeks after stopping his thyroid supplementation. He was readmitted to our hospital and was again diagnosed with rhabdomyolysis secondary to Hashimoto’s thyroiditis. Serological thyroid function and muscle enzymes normalized after the second dose of levothyroxine. The patient has remained symptom-free without recurrent episodes of rhabdomyolysis at two-year follow-up.