The amounts of six heavy metals (Fe, Cd, Co, Cr, Ni, and Pb) were measured in all 15 sediment samples, which included three drains south of Manzala Lake (Egypt). The possible environmental risks of metals in the sediment of the three drains were investigated using soil indices and risk assessment. Results showed that heavy metal contamination was found at the studied sites along the three drains, and pollution levels varied depending on metals and sites. The mean concentration (mgkg-1) ranked in the order of Fe(3950.24) ˃ Cd(22.36) ˃ Cr(21.15) ˃ Co(19.01) ˃ Pb(14.16) ˃ Ni(10.40) for Faraskour drain, Fe (5067.80) ˃ Cd (30.29) ˃ Co (18.97) ˃ Cr (16.90) ˃ Ni(15.03) ˃ Pb(12.16) for Al-Etaiwy drain and Fe(12.56.12) ˃ Cd(19.60) ˃ Co(17.15) ˃ Ni(14.88) ˃ Cr(10.10) ˃ Pb(10.03) for Ramsis drain. The mean ranges of enrichment factor for Cd, Co, Pb, Ni and Cr were 167.46-3858.37, 6.11-51.78, 4.38-31.20, 1.07-11.84 and 0.61-7.43, respectively. The average degree of contamination revealed that the majority of the sites had reached very high levels of pollution, with the exception of site 1, which had reached a moderate level of contamination. The ecological risk of heavy metals can be ranked as follows: Cd>Co>Pb>Ni>Cr, and the PERI were 930.99, 1173.17 and 818.48 in the Faraskour, Al-Etaiwy and Ramsis drains, respectively. To decrease pollution, it was determined that more effective restrictions on Cd and Co were needed.