4-Aminobenzohydrazide (1) undergoes twice chloroacetylation at both primary amine and hhydrazide-NH2 functions. The conforming bis-chloroacetamide derivative 3 that produced was reacted with different sulfur reagents (namely; 2-mercaptobenzothiazole, 6-amino-2-mercaptopyrimidin-4-ol, and 2-mercapto-4,6-dimethyl-nicotinonitrile) to give new bis-sulfide compounds 5, 7 and 9, respectively. The newly synthesized bis-chloroacetamide and their corresponding sulfides were screened for antimicrobial and antioxidant potential. The sulfide derivative 7 exhibited the most potent activity against Staphylococcus aureus and Pseudomonas aeruginosa with inhibition activities 83.3% and 78.3%, respectively. Moreover, the sulfide derivative 7 showed the highest antioxidant activity with an inhibition ratio = 85.9%, which comes very close to L-ascorbic acid.

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