Natural product compounds havea nitrogen or oxygen heterocycles such as polyphenolic compounds and alkaloids are broad in nature and therapeutic plants, specifically, have end up being a wellspring of practically limitless N-determined construction .This study aims to study the effect of natural heterocyclic compounds constittents of the leaves of Eruca sativa as anticancer and antioxidant agents. Also, an eco-friendly synthesizes copper and pladium nanoparticles using E. sativa leaves’s aqueous extract and to evaluate antioxidant and cytotoxic activities of both CuONPs and PdNPs and compare with aqaus extract of E. sativa. Nanoparticles produced were elucidated by UV– Vis spectroscopy, FT-IR, XRD, and HR-TEM analysis. Then, the purified nanoparticles for both copper and palladium as spherical red pellets were then investigated for antioxidant assay using DPPH method. In addition, to assess the Cytotoxic effect of the CuNPs & PdNPs on Human Colon carcinoma (HCT-116), Human Lung carcinoma (A549) and the normal human liver fibroblast cell line (WISH) was assessed by MTT assay. The study observed the IC50 value of PdNPs has most potent cytotoxic activity on different cell lines against as 14.4 ±0.2 µg/ml,18.3 ± 1.9 µg/ml and 43.1± 3.14 µg/ml for HCT-116, A549 and WISH cell lines respectively .
Introduction: The main difficulties of zirconia ceramics application are related to establishing a stable and long-lasting adhesion to the cement. Aim: To evaluate the microtensile bond strength (mTBS) of bonding between different types of cements and zirconia ceramic using an in vitro study. Materials and methods: 48 teeth extracted human teeth were used, and 84 dentin blocks were made. They were fixed to the special prepared cylinders of zirconia ceramics IPS e.max ZirCAD Prime (Ivoclar Vivadent) with different type of cements. Test specimens (sticks), with size 2х2х20 mm, were cut from the created ceramic-cement-dentin constructions. The sticks were subjected to test of measuring micro-TBS. Results: The results demonstrated the highest values of 3.3 MPa in Speed Cem Plus cement. Weaker bond strength was registered in Panavia V5 and Variolink Esthetic DC with 2.8 and 2.4 МРа, respectively. The corresponding values of Thera Cem - 2 МРа and RelyX Luting Plus Automix - 1.9 МРа were relatively identical but significantly lower. The weakest bond strength of 1.6 MPa was measured in relation to Fuji Plus Caps. Results from the comparative tensile strength analysis of non-sandblasted ceramics were similar to these of the processed ones but significantly lower values of approximately three times were observed. The strongest bond occurred in relation to Speed Cem Plus – 1.2 МРа, followed by Panavia V5 – 0.9 МРа and Variolink Esthetic DC – 0.8 МРа. The tensile strength of Thera Cem and RelyX Luting Plus Automix was 0.6 МРа, whereas Fuji Plus Caps had value of 0.5 МРа. Conclusions: Preliminary sandblasting processing of zirconia surface with Al2O3 considerably improves adhesion to cement. Bond strength increases together with the application of resin cements with primers, as optimal results are achieved with MDP primers.
The TiO2 opals were functionalized with palladium nanoparticles and were used in the fabrication of chemical sensors for the detection of hydrogen (H2) using hydrogen concentrations in the order of parts per million (ppm) at moderate temperatures (300-450°C). The results showed that the inclusion of palladium nanoparticles on the surface of TiO2 inverse opals improves the sensing performance. Particularly the sensor response increased two-fold and the time constants were reduced to several seconds, in comparison with the sensor without palladium nanoparticles at the optimal sensor operating temperature. These results show that the TiO2 inverse opals are an excellent option in the development of third-generation gas sensors.
Background: Slow coronary flow (SCF) is an angiographic finding characterized with delayed opacification of epicardial coronary arteries without obstructive coronary artery disease, coronary artery ectasia, or myocardial dysfunction. SCF is associated with repeat coronary angiography due to recurrent angina, malignant arrhythmias and even sudden cardiac death. Index of cardiac electrophysiological balance (iCEB) (QT/QRS) has been described as a novel predictor of malignant ventricular arrhythmias. The aim of this study is to evaluate the İCEB values in patients with SCF.\nMaterial and Methods: Forty SCF patients and 40 controls were enrolled to the study. Coronary flow rates of all participants were documented by TIMI frame count. First; QRS, QT, Tp-e values were measured manually and QTc interval was calculated by using Bazett\'s formula. Then, Tp-e/QT, QT/QRS and cQT/QRS ratios were calculated.\nResults: There was no significant statistical difference between the two groups in terms of basic demographic characters. QTc and Tp-e intervals, QT/QRS and Tp-e/QT ratios were significantly higher in SCF patients (P<0.05).\nConclusions: This study revealed that iCEB and transmural dispersion of repolarization indices were significantly increased in SCF patients. \nKeywords: Slow coronary flow, Cardiac electrophysiological balance (iCEB), Tp-e interval, Tp-e/QT ratio
In this paper, we study of a mathematical problem for dynamic contact between two thermo-electro-viscoelastic bodies with normal compliance, adhesion and damage. The damage of the material caused by elastic \n deformations. The evolution of the damage is described by an inclusion of parabolic type. The evolution of the bonding field is described by a first order differential equation. We derive variational formulation for the model and prove an existence and uniqueness result of the weak solution. The proof is based on arguments of time dependent variational inequalities, parabolic inequalities and Banach fixed point theorem.
No case report has been available on septicemia owing to Vibrio vulnificus (V. vulnificus) and Aeromonas species (sp.) in the same patient. We herein report a rare case of septicemia owing to V. vulnificus and Aeromonas sp. in the same patient. Our patient was a 61-year-old Japanese man with uncompensated liver cirrhosis due to hepatitis C virus. He experienced high fever 2 days after consuming raw fish and was admitted to our hospital. V. vulnificus was isolated via blood culture, for which a diagnosis of septicemia owing to V. vulnificus was subsequently established. After antimicrobial agent administration, the patient was able to recover. However, 11 months after the first admission, the patient was readmitted to our hospital for another incidence of high fever. Aeromonas hydrophila was subsequently isolated via blood culture, for which a diagnosis of Aeromonas septicemia was established. After antimicrobial agent administration, the patient was able to recover again. Neither septic shock nor skin and soft tissue lesions were found in the present case during both episodes of septicemias.
