The patient was Japanese woman who was diagnosed as ulcerative colitis (UC) at 37 years old and underwent total colectomy a year after because of unsuccessful pharmacotherapies for UC. At 15 years after colectomy, she developed liver dysfunction secondary to type 1 autoimmune hepatitis (AIH), which responded to corticosteroids and went into remission without relapse for 10 years. Although cases of AIH or AIH/ primary sclerosing cholangitis overlap syndrome with concomitant UC have been sporadically reported, cases in which the onset of AIH was after colectomy for UC were estimated to be rare.

Speaker Verification is a popularly used authentication mechanism for verifying the voiceprints of the identity claim for accessing the service. The speaker related speech features are the most important clues for recognizing a speaker in a speaker verification system. Protecting feature template is a challenging task against impersonation, eavesdropping attack and intra-user variability. Hence in the proposed system, feature extraction is done by using four feature extraction techniques and feature selection is done on the extracted features using optimization algorithm. The optimized features are watermarked by using bits of an image taken from the image database. The Least Significant Bit (LSB) of the selected image is taken and embedded with the considered features. Then, the watermarked feature set is encrypted by using the proposed Advanced Encryption Standard (AES). Finally, the proposed system is tested under various quality metrics to quantify the performance of the speaker verification system under statistical and brute-force attacks.

The aim of the present study was to show the effect of carbon-nitrogen ratio (C/N ratio) and initial pH culture medium on the production of biomass and L-(+)-lactic acid by Lactobacillus casei subsp casei NRRL-441. The response surface methodology implementing a Box-Behnken experimental design yields estimation of the optimal culture conditions (within the selected variables range). Lactose and yeast extract, casein peptone and meat extract were the carbon and nitrogen main sources. The maximum biomass (4.07gL-1) and lactic acid (27.56 gL-1) productions were obtained when initial pH was 7.5 and C/N ratio of 4.13. The kinetic reaction exerted under the optimal conditions was modeled using an aggregated Monod, Luedeking and Piret models, respectively. Such conditions yield to propose a modified culture medium with yeast extract (27 gL-1) as the nitrogen source and lactose (20 gL-1) as carbon source. The achieved optimal C/N ratio was fixed to 4.13. Yeast extract replaces casein peptone as well as meat extract with a positive effect on lactic acid production yielding a concentration of 30.06 gL-1. A novel parametric identification method yields the characterization of the lactic acid production under the selected experimental conditions. The estimated model correlates with experimental data with enough accuracy.

This research was designed to study the phytogeographical distribution and some ecological aspects of the endemic flora of Zaini Valley Chitral situated in the famous Hindukush region of Pakistan. The entire area was surveyed during 2018-2019 in both spring and summer season for the collection of endemic species. A total of 10 endemic species with a total of 9 genera and 7 families were collected and identified. Asteraceae was the dominant family with 3 species, second dominant was Primulaceae with 2 species, while Apiaceae, Amaryllidaceae, Brassicaceae, Poaceae and Polygonaceae with 1 species each. The leading life form classes were Therophytes and Chamaephytes with contribution of 3 species each, followed by Geophytes and Hemicryptophytes having 2 species each. Nanophylls was leading leaf size class with 5 species, followed by Leptophylls with 3 species and Microphylls and Mesophylls were with 1 species each. The research area came under Irano-Turanian Phytogeographical region, which is well known for endemic species. The endemic species collected from the area including Pimpinella stewartii, Anaphalis chitralensis, Cousinia chitralensis, Androsace himalaica, Polygonum cognatum, Calamagrostis dicora, Androsace staintonii, Tricholepis tibetica, Allium chitralicum and Draba pakistanica. During our studies Calamagrostis dicora was reported for the first time from the study area.